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Bone & Joint Health

Bone Essense with Kolla2® and more
U. S. Patent #: 6838440

60 capsules
buy 6 get 1 for free
buy 12 get 3 for free

Bone Essense with Kolla2® and more is a U.S. Patented formula for promoting bone & joint health and relieving joint stress.

  • A U.S. Patented and clinically tested product (No. 6838440) with unique formula for bone & joint health improvement.
  • Improve joint comfort and function.*
  • Helps lubricate, rejuvenate and re-hydrate for general joints health.*
  • Helps maintain, support and lubricate joints, ligaments and bones through nutrition and supplementation.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Bone Essense is developed based on latest breakthroughs in research of human bone and joint health. When people are aging, our bodies begin a gradual loss of collagen, and due to physical degradation, cartilage between the joints becomes thin and uneven, causing stress when joints move. Supplementing with Kolla2 (patented collagen type II) replenishes body's collagen II. Taken orally, Kolla2 will be digested, absorbed and spread through the body, especially to the joints. These digested product contains rare amino acids and special peptides needed for bones and joints, and will help re-hydrate, rejuvenate, maintain and support bone and joint cartilage.

Bone Essense also provides calcium. We now know calcium alone—even combined with vitamin D—does not do enough to rebalance natural bone loss. Coupled with Kolla2, calcium can be better absorbed by human body. Combining Kolla2 and calcium with Glucosamine, Chondroitin Sulphate, MSM, and Hyaluronic Acid, this product helps strengthen bone quality and health. In addition, Bone Essense lubricates joints and boosts joint flexibility. This unique Bone Essence formula works in a remarkably rapid manner to continually maintain and support joint and bone health.

Bone Essense is developed by Best in Nature®. Our superior and innovative formulations are scientifically designed and researched. Best in Nature® products are manufactured at cGMP certified facilities and distributed globally.

3/9/06, CollagenNutraceuticals announced that after taking the main ingredient of Bone Essense , Kolla2, for six weeks, animal with joint canine deficiencies were restored to normal function. X-ray figure shows a right joint cartilage's thickness (RightJointHip) significantly increased -

Before taking type II Kolla 2

After taking type II Kolla 2

Supplement Facts
Serving Size: 2 Capsules                      Servings Per Container: 30
Amount Per Serving % Daily Value
Calcium(as calcium citrate) 100 mg 10%
Kolla2 (proprietary Unhydrolyzed Chicken Sternal Collagen Type II) 600 mg *
Glucosamine HCI 300 mg *
Chondrotin Sulphate(as Chondroitin Sulfate Sodium) 80 mg *
MSM(Methysulfonylmethane) 60mg *
* Daily Value not established.

Other Ingredients: gelatin and purified water.

 Suggested Use:
Take two capsules twice daily with meals as a dietary supplement.

*Please check our Mandarin product detail page for “Conditions matched to specific testimonials?

    --------2019 testimonials--------

  • Mr. Xia from Beijing left a review: My father has been using Bone Essence for many years and has seen significant effects on his arthritis. My mom used to pain in her wrists and knees, and her wrists would hurt so much she couldn’t cook. After using Bone Essence, she experienced less pains and virtually no pains now. Now both of my parents highly trust the product and have been taking it daily for years. They even bring it with them on vacations to protect and maintain their bone health. Buying multiple sets can be pretty economical and we can accumulate points for rewards because they look after old customers.

  • Ms. Xu from Hainan left Best in Nature a review on Weidian: "I've bought Bone Essence, Vigorheart, and Vitabrain many times because they work really well. My knees used to rattle when I sat down or stood up and I would have to mentally prepare myself for the pain. After taking Bone Essense, I noticed a significant improvement from before. I’ve been using Bone Essence for over two years and I will continue purchasing for my long term prevention and maintenance.”

    --------2018 testimonials--------

  • [Bone Essense] improved knee pains and ability to walk. Ms. Pan from Shanghai let us know that she's had arthritis on her knees for many years. Last year, her right knee was hurting her especially. Her doctor said that the abrasion on her knees were too serious and recommended surgery. Ms. Pan was too scared to do a surgery and was afraid of the side effects of a surgery and chose for a more conservative recovery. She randomly heard a friend talk about [Bone Essense] and after using it for 6 months, she's been able to walk again! Ms. Pan said that [Bone Essense] was especially effective for her and she plans to keep using it and hopes her knees will be fully recovered soon.

  • [Bone Essense] helped with rheumatoid arthritis. Mr. Guo from Beijing, China, left a message for Best in Nature: I’ve been buying [Bone Essense] since 2006. My mom is 60+ years old and spent long periods of time in high temperature warehouses. The temperature difference with the outside was too much and she developed rheumatoid arthritis. The doctor said that if they performed surgery, there was a possibility of paralysis, so we decided it was better to treat her with more conservative methods. Afterwards, I heard from a neighbor that [Bone Essense ] worked pretty well for him. He used to be worried about walking but with the help of [Bone Essense], would go on walks and even exercise. I got a set for my mother so she could take it for about three months and she saw visible improvements. My mom says every day that, “[Bone Essense] is the best!” In the summer months she used to wear another layer of pants, need to take a break after a short walk, and her knees couldn’t support the weight of her body; but now everything is great. Since she had been consistently taking [Bone Essense], when she fell down the stairs two years ago, we all really thought she would get a fracture but nothing happened! Recently, my mother-in-law strained her lumbar so I bought her [Bone Essense] to help her recover. I’ve looked into [Bone Essense] and its combination of Type II Collagen and calcium is more effective than just regular calcium supplements. For my dear mom’s health, I will be a consistent customer!

  • Improved Rheumatoid arthritis pains and gained strength to travel. Mr. Zhang from Tianjin left Best in Nature a message on WeChat: My partner has had serious rheumatoid arthritis for years. It was so bad last year that she had trouble walking around our neighborhood. In November of 2017, our friends from the US brought us a few bottles of [Bone Essense]. My wife took it for around two months and noticed a visible improvement in her legs. We eventually found the WeChat store ourselves for [Bone Essense] and have since bought [Bone Essense] twice. This year, we went on vacations in both May and July to Guizhou and Mt. Huang. We were the oldest in our tour groups at 70 years old, but we were not any slower than the rest of the people. At Mt. Huang, we hiked for 10 km the first day and 6 km the second day, and my wife did just fine and did not feel any pain or discomfort. We are very grateful to Best in Nature for [e Essense] and will continue using it to maintain our joints and bones.

  • Bone Essense for three months helped with legs getting more energy and being able to enjoy traveling. Mr. Zhang of Tianjin left Best in Nature a message on Weidian: "My wife has had Rheumatoid Arthritis for many years and last year was especially rough on her. Walking for just a little bit would be tiring for her legs and she'd have to take a break. After using [Bone Essense] for three months, she had the strength and willingness to walk again. Earlier in the spring, we traveled for six days and even though we were the oldest in our travel group, we didn't walk less than the young people in the group. We're grateful for [Bone Essense] and the customer service team's support and will be buying two more sets of [Bone Essense]. I hope my wife's body will get better and better."

  • Famous celebrity Mr. Qiu from Chongqing left us a WeChat message: My mother and mother-in-law are both 80+ years old and using your products such as Bone Essense and Vitabrain. My mother-in-law has always had joint pain which has fortunately gone away thanks to Bone Essense. Now my whole family shops on your website and we find it very convenient. Thank you for coming up with such great products and allowing us to live such happy and productive lives. Now everybody is more health conscious, and we’ve recommended your products to many of our friends in Chongqing.

  • Mrs. Luo is from New York and loves photography very much. She is 73 years old now and has been taking [Bone Essense] since 60 years old. When she goes out to photograph, her good health support walking, hiking and other activities. Mrs. Luo said, “My knees used to rattle when I was walking, my friend recommended [Bone Essense] to me, so I went to “Starside Drugs” Pharmacy in New York to try it. It has been so effective after I intake for a week, and I think it should be one of the most key component, Kolla 2, very good source of cartilage. [Bone Essense] is helpful to me, I also have recommended it to my friends, and ordered it to my relatives as a gift. In addition, I am taking [VitaBrain] , [VigorHeart] and [Eye Care Essense], all branded by Best in Nature.”

    --------2017 testimonials--------

  • Mrs. Zheng from South California, 50 years old (phone no. 657-444-xxxx). In recent years, she used cell phone and computer too much, so her right thumb joint was very painful, even not be able to hold the steering wheel when she was driving, then use of a hand bandage is expect to ease discomfort. After taking [Bone Essense] for 6 months as daily supplement, now the thumb joint pain has gone and able to use cell phone freely. She is very grateful for the help of [Bone Essense].

  • Using [Bone Essense] helped with knee joints. Ms. Guo from Walnut, Los Angeles (909-598-63XX). Her mother-in-law is 85 years old and lives in China. She had serious swelling in her knees that made it difficult to go up or down the stairs. She was especially anxious and scared to go down the stairs, because that meant she would have to go back up the stairs as well, and going up the stairs was the hardest. She took [Bone Essense] for two years, and now going up and down the stairs is completely fine and her knees are normal. Ms. Guo’s brother-in-law’s knees used to hurt too. Half a year ago, he started trying [Bone Essense]. He felt the results were pretty great, so he takes it long term now.

  • Mrs. Wang from Beijing has shoulder periarthritis for couple of years. She tried a lot of products, but none of them really helped. After taking [Bone Essens] for several days, the shoulder pain has gone. To maintain the good effect, she continues taking [Bone Essens] every day. She also recommended[Bone Essense]to a friend who has knee pain, and he feels much better right now. Mrs. Wang would like to express her gratefulness to Best in Nature.

  • Doctor Xudong Yu’s mother from Wenzhou had bone spur and knee edema for couple years. she could not stand for half hour and go up and down stairs easily. After taking [Bone Essense], her discomfort was gone. She recommended[Bone Essense[to her friends who also have the same symptoms. They all felt much better after giving it a try and now they trust the products quality of Best in Nature.

  • 1/3/2017, Mrs. Yu called to reorder(Bone Essense),(Vita Brain)and (Eye Care Essense)for her parents. She said "My father has macular degeneration and poor vision, he always sees something with black-shadows; my mother has osteoporosis, she often felt backache, and she has high risk of fracture, also she has mild Alzheimer's with poor memory and not able to go out alone." They trust Best in Nature very much. Her mother felt better with (Bone Essense), and her backache is gone. She also felt her memory improved and able to go out by herself after taking (Vita Brain). Her father also got better after taking(Eye Care Essence), his macular degeneration and sight have been improved. Mrs. Yu orders these 3 products one year supplies for her parents.

    --------2016 testimonials--------

  • Mr. Zheng from Shandong,at his 60s,(phone #: +86-136-4531-21xx ) , the founder of a private business, had six ribs fractures after a car accident 6 months ago. The doctor said that at this age it was not easy to fully recover and might take longer. With a friend's recommendation, Mr. Zheng took[Bone Essense]from Best in Nature, which is an unique formula for bone & joint health improvement as supplements. He kept taking two capsules [Bone Essense]with breakfast and dinner daily assisted by other treatments. Mr. Zheng has fully recovered with the help of [Bone Essense]. Now he can play erhu (Chinese violin) and take care of grandchild. Mr. Zheng is very happy and would like to express his appreciation for Best in Nature and is willing to share with others. His friend ordered [Bone Essense]online again for him.

  • Better with [Bone Essense] Mr. Yu from Zhejiang sent Best in Nature a message saying, his father suffered from Chronic arthritis, bone spurs, water on the knee, accompanied by pain, swelling of the legs. It was very difficult for him to move. Because of his age, the doctor would not recommend surgery and suggest conservative treatment instead. However, after taking [Bone Essense] for only ten days, leg swelling began to subside and the pain decreased significantly. His father is free to walk around as before. His father insists on taking [Bone Essense] since then. "[Bone Essense] is the best product I have ever used" his father said and then asked. "Is [Bone Essense] expensive?" Mr. Yu replied "This product is affordable and the price is reasonable. It is the best bone product in the U.S". Mr. Yu passed his father's appreciation and gratefulness to Best in Nature.

  • Improve joint pain in six weeks with [Bone Essense] Li Jiang posted on Wechat " I started taking [Bone Essense] since May this year, after 6 weeks, the knee pain is gone. Shoulder pain is still there but much better than before. "She insists on taking [Bone Essense] since then. She said [Bone Essense] worked very well for her and she would recommend [Bone Essense] to her friends and family! She also said, she's the type of person who is dedicated to maintaining a healthy diet and exercise. But due to the pain from joint degeneration, "it hurts when my right knee bent every time I'm doing yoga and the right knee doesn't feel comfortable when I walk. By taking [Bone Essense] for a while, the pain is gone." Mrs. Li concluded that the knee pain happens at our age as well as the menopausal problem. The body metabolism is not powerful as before. It's really necessary to start taking nutrition products. There are so many products out there on the market and it's hard to tell which one is better. Mrs. Li strongly recommend [Bone Essense]!

  • Ease hip pain with [Bone Essense] On July 13th, 2016, Mrs. Pengying Zhu from Hangzhou (1885811019XX) sent us a message, her father suffers hip pain for years. He felt significantly improved after taking [Bone Essense] for one year. Her father-in-law has joint degeneration and shoulder periarthritis and also patella fracture and joint hyperplasia problems. Now she ordered more [Bone Essense] and [Bone Essense Cream] at [Best in Nature]. She said," [Bone Essense] is amazingly helpful and I'm waiting to receive the order soon!"

  • Ease joint pain, finger stiffness and difficulties for upstairs and downstairs. Mrs. Song (Tel 13302284XXX) passed the gratefulness from her 62-years old mother to Best in Nature on June 13,2016 by WeChat. Mrs. Song said that her mother once suffered from severe pain on her joints, elbow, leg joints and waist for a long time, especially it was very difficult for her to go downstairs. Her test of rheumatoid arthritis is always negative, the doctor told her that she may disabled from osteoarthritis. However, after Mrs. Song ordered her BONE ESSENSE for her mother as a trial last year, her mother can move freely. Started from the beginning of 2016, Mrs. Song not only keeps buying BONE ESSENSE for her mother, but also purchases more BONE ESSENCE for her friends' parents.

  • Knee weakness has been greatly improved, can go climbing now. Mrs. Ding (phone number: 186101753xx) from Qingdao said that twenty years ago, her mother's knee could not bend. Last year, the knee problem got worse, joint pain increased, and she could hardly move. By taking BONE ESSENSE for a while, she can walk to park, then go climbing Er long mountain with her family, and surprisingly, she climbed even faster than others. Mrs. Ding concluded that BONE ESSENSE is really effective, and the performance of is much better than taking a high-profile Australia imported bone health product.

  • Relief Joint Degeneration, Knee Rattling, and Osteoporosis Problems. At the beginning of the year, Mrs. Shen (witness telephone 626-458-67XX), who lives in San Gabriel, CA, ordered 25 bottles of BONE ESSENSE as gifts to her relatives in Taiwan. She told us that she has been taking BONE ESSENSE over the past year, which helped relieving her bone and joint degeneration, knee rattling, osteoporosis and other problems. Mrs. Shen strongly agreed that the products really worked and would like to recommend it to people around her who have similar problems!

    --------2015 testimonials--------

  • Comfort knee with [Bone Essense]. Mr. Chen (Wenzhou, China) contacted customer service of Best in Nature through Wechat, ordered two packages[Bone Essense]. He said [Bone Essense] made his knees felt much better than before. In past two weeks, Mr. Chen ordered 7 packages of [Bone Essense] in total for family and friends.

  • Ease knee pain. Mr. Yan from Virginia (Tel: 804-270-6392) called customer representative of Best in Nature, said he is 72 years old, suffered osteoporosis and arthritis, which became even worse on rainy days. With recommendation from friends, he started taking [Bone Essense], after 4 weeks, the knee pain is gone. Now he can move his joint freely, and feels much more energetic than before. His wife is also taking [Bone Essense] now. Mr. Yan called in to share his testimonial.

  • Keep on taking [Bone Essense] & [Vigorheart], gave birth to baby successfully. Mr. Lee, (Chengdu, China) an entrepreneur, often ordered [Bone Essense]and [Vigorheart]on and , not only for himself , gave many relatives and friends. His wife, six months before her pregnancy, started taking [Bone Essense] and[Vigorheart]orally, and gave birth to a healthy baby.

  • Improve rattling and trembling when go upstairs. Ms. Zhou (Rowland Heights, CA, Tel: 626-318-xxxx) suffered knee pain and rattling when goes upstairs. She felt significantly improved after Bone Essense]. Ms. Zhou’s sister is also benefited by[Bone Essense]. Ms. Zhou also takes [Best Rei-Shi Plus], which helped her sleep better at night. Her appetite is much better.

  • Improve heel tingling. Professor Wei, Guangzhou (Tel 1881928XXX), is 50 years old. Due to long time standing for work, Prof. Wei felt heel & ankle soreness and tingling for years. Recently, the heel spur pain got worse. Prof. Wei even dare not to put her feet on ground. Prof. Wei's friend Lai ordered her BONE ESSENSE, and she took orally for two courses. Now her heel spur pain was greatly improved, and she does not feel pain any more. She said that BONE ESSENSE worked very well for her heel!

  • Relieve nocturnal leg cramps. Mrs. Zhong (Tel 13922315XXX), from Guangzhou Bai Yun District, is 78 years old. She has leg cramps every night during sleep, which caused severe pain and bad sleep quality. Mrs. Zhong tried many treatments, such as applying hot compress, which are not really effective to her. One month ago, Mrs. Zhong started taking BONE ESSENSE. To her surprise, now, she does not have leg cramps anymore. Mrs. Zhong happily said she would recommend BONE ESSENSE to her friends!

  • Improving lumbocrural pain.Mr. Lai, San Francisco (415-812-5XXX), called saying that his 83 years old mother had been suffering from lumbocrural pain for years. His mother got worse during the cold winter and had to take painkillers. However, Mr. Lai ordered her BONE ESSENSE, and she took orally for a month. Mrs Lai does not feel the lumbocrural pain anymore, she enjoys talking about BONE ESSENSE's effectiveness. Recently, she ordered BONE ESSENSE for her friends living in Europe.

  • Ease joint pain. Mrs. Chen (Tel 13302284XXX) from Guangzhou, suffered joint pain for a long time. The pain made her no fun of going out to town. She was also associated with high blood sugar and stomach discomfort. As a result, certain medicines are not suitable for her treatment. With a friend's suggestion, Mrs. Chen started taking BONE ESSENSE. After few courses, she felt her joints were significantly improved. Now, Mrs. Chen can not only hang out but also go for a trip to Europe, she said: "I do not need people's help to walk at all. I never thought life can be this good!" Recently, Ms. Chen brought her family and friends six other courses of BONE ESSENSE, and she would like to share her experience with everyone.

  • Improve joint pain, weakness, and cracking sound in knee. Serena Wang (Tel 909-865-XXXX) has been suffering from joint pain, weakness, and cracking sound in knee over the years. Recently, her doctor recommended her to take BONE ESSENCE. After taking two weeks, she felt positive effects, and insist on taking BONE ESSENCE. So far, the joint ache, weakness, and the knee sound were great improved, and the BMD also increased. March 12, 2015, Ms. Wang visited and purchased more BONE ESSENCE for her friends to share.

  • Improve catagmatic range. Fan Tongxing, Tianjin Foreign Language School founder, fractures several times over the years due to osteoporosis. She had ate a lot of health care products, but none of them really helped. Some even hurt stomach. A year ago, her student Mr. Chen (Tel 909-210-39XX) bought her BONE ESSENCE. With taking BONE ESSENCE, her stomach feel very comfortable, and most importantly, the catagmatic range is becoming significantly better.

  • Relieve lumbar disc herniation. February 24, 2015, we got a message from Mr. Chen, which said he was graduated from the Military Academy, and due to his long term job, he has been suffering from lumbar disc for more than three years. During these years, Mr. Chen tried many treatments, e.g. massage, Acupuncture, chiro traction, etc. However, none of them was helped. Last year, his wife bought Bone Essence for him. After taking Bone Essense for a few months, 4 capsules daily, the pain was gone and he felt relieved from the discomfort, thus he wrote the letter to express his appreciation to Best in Nature.

  • Improve elbow joint pain. January 10, 2015, Jack, a young man from Melbourne, Australia, called in and said he needed an urgent purchase since he was leaving the US the next day. He said lots of people in Australia knew about Bone Essense. It was his mom who recommended Bone Essense to his father at first, since the results were very good. His father's old elbow joint pain came back again because of the cold weather. After taking Bone Essense, the pain was gone! With complete satisfaction about the product, his dad asked him to buy more Bone Essense, so Jack rushed in to make the purchase on this rainy weekend.

  • Bony spur, swelling, and difficulty walking. Ms. Li, New Jersey (Tel: 201-461-18XX), is a regular customer of our company. In the past, she used to order BONE ESSENCE every three months. But recently, Ms. Li orders our product every month, and she even doubled her order every time. She even nicknamed herself the "Seller". Ms. Li said, since taking BONE ESSENCE, she felt much better from suffering spur, swelling, and pain that caused by degenerative osteoarthropathy. Later on, she recommended BONE ESSENCE to her old sister, who was suffering the weakness of upper and lower limbs. Ms. Li's sister tried lots of ways in the past, such as acupuncture and taking some other health products. Unfortunately, none of them worked. However, since starting taking one set of BONE ESSENCE, Ms. Li's sister can bend her knees, and she can even go for walks now. Ms. Li is professionally doing scientific research, and she would not follow people's recommendation blindly. After doing deep research about BONE ESSENCE's ingredients, she said "KOLLA2 is amazingly helpful!"

  • Low bone density, cracking sound in knee. Mr. Zhang, int'l student in Los Angeles (Tel: 949-784-99XX), said his aunt, 65-year-old, living in Ningbo, China, had bone density test and her index was -2.6. After taking Bone Essense for 6 weeks, the bone density index was increased up to -2.0, and the cracking sound in her knees was gone (Editor's note: bone density index -1 to -2.5 indicates low bone density, below -2.5 indicates osteoporosis). Last year, his aunt fell over and broke her wrist. She took calcium and magnesium supplement for more than 6 months, but the bone density index didn't improve. Mr. Zhang's friend told him that type II collagen (Kolla2) would better maintenance and support bones and joints for senior people. Thought about giving it a try, Mr. Zhang bought his aunt one course of Bone Essense. Yesterday, his aunt sent him a message through Wechat said the latest test result showed her bone density significantly improved. And she asked Mr. Zhang to mail her more Bone Essense. Mr. Zhang called in to express thanks!

  • Joint and knee discomfort. Ms. Wu, California (Tel: 650-255-38xx) had discomfort and stress at her left leg and knee and cannot lay straight or walk without a crutch. Her doctor advised that a surgery is needed. She started taking Bone Essense since April 2013, four capsules a day. Now the discomfort and stress disappear, and she is free to walk around or even drive a car. She told her friends that the surgery for her legs is no longer needed. She owes this to Bone Essense.

  • Difficulty walking. Mr. Bingquan Sun, Canada (Tel: 416-696-6988 Home, 647-896-2890 Mobile), 87 years old, is an immigrant from Taiwan. In his early years (1946 - 1959), he served as a KMT naval officer on the Tai Kang battle ship. Years at sea, the living conditions are very poor. There was no air conditioning and he could only sleep in the carrier fort during summer. When wake up in the morning, his body was coved with dew. Later on he suffered severe joint discomfort. He could not bend his knees, and can only dragging legs when walking. In recent years, he tried a lot of medicines and health products to maintenance and support, but none of them works. Since June 2013, he started taking two courses of , his joint discomfort is gone and he can even go for a walk. He said,?is amazing, please take my real name and phone number as witness, to help everyone from suffering joint discomfort!

  • Swollen fingers, wrists and elbows. I worked for a clothing manufacturing company in San Francisco. My fingers, wrists, and elbows are swollen and feel so uncomfortable in that I cannot even hold up the cooking knife. I ended up quitting my job. I started to take Bone Essense for only a week. The results amazed me. All my discomforts, stress and swollenness are gone, and I can go back to work now. I cannot wait to share this exciting experience with my co-workers. At first, they all laughed at me for advertising the product for the company. However, after seeing that my hands are getting better, they started believing me. We even order Bone Essense together (Ms. Qin, San Francisco, 415-986-22XX).

  • No side effects. Bone Essense?is the best product I have ever used. This health product is very gentle; it does not give me any side effects. Yet it makes me feel better and better every day. I really appreciate Best in Nature for bringing such a great product to the consumers (DAVID CHOU, Indiana, 765-977-xx34)

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